Can redox imbalance predict abnormal foetal development?
| Autor: | Kinga Tobola-Wrobel, Marta Napierała, Jacek Brazert, Sandra Radzicka-Mularczyk, Piotr Dydowicz, Ewa Florek, Marek Pietryga, Katarzyna Ziolkowska |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Trolox equivalent antioxidant capacity medicine.disease_cause Redox Antioxidants Nitric oxide Fetal Development chemistry.chemical_compound Fetus Pregnancy Internal medicine Humans Medicine Retrospective Studies business.industry Obstetrics and Gynecology Odds ratio Glutathione medicine.disease Endocrinology chemistry Female business Oxidation-Reduction Biomarkers Oxidative stress |
| Zdroj: | Ginekologia Polska. 93:209-216 |
| ISSN: | 2543-6767 0017-0011 |
| DOI: | 10.5603/gp.a2021.0122 |
| Popis: | Objectives: Based on the current state of knowledge, elevated levels of oxidative stress markers may be considered as risk factors for pregnancy complications. The aim of the research was to assess the correlation between selected oxidative stress biomarkers with the occurrence of foetal chromosomal aberration and congenital malformations. Material and methods : This retrospective research lasted for two years. The purpose was to determine serum levels of selected oxidative stress markers, including total protein (TP), glutathione (GSH), S-nitrosothiols (RSNO), nitric oxide (NO), trolox equivalent antioxidant capacity (TEAC) and glutathione S-transferase (GST) at 11–13 + 6 gestational weeks in 38 women with confirmed foetal developmental abnormalities and in 34 healthy pregnancies in order to assess their utility as predictors of abnormal foetal development. Results: Serum concentrations of TP (56.90 ± 5.30 vs 69.1 ± 15.30 mg/mL), TEAC (4.93 ± 0.82 vs 5.64 ± 0.74 μM/mL) and GST (15.94 ± 4.52 vs 21.72 ± 6.81 nM/min/mg) were statistically significantly (p < 0.05) lower in the group of patients with developmental abnormalities in the fetus, whereas GSH levels (6.43 ± 1.24 vs 4.98 ± 1.88 nM/mg) were significantly higher, compared to the group of healthy fetuses. There were no differences in the concentration of these markers between chromosomal aberrations and fetal dysmorphia in subjects. A significant difference in odds ratio obtained for GSH (OR = 0.57, 95% CL: 0.40–0.80) indicates that its higher concentration can relate to reduced risk of developmental abnormalities, whereas odds ratio for TP (OR=1.11, 95% CL: 1.04–1.17), TEAC (OR = 3.54, 95% CL: 1.56–8.05) and GST (OR = 1.18, 95% CL: 1.03–1.17) indicate that their elevation may increase the risk of developmental abnormalities Conclusions: Elevated levels of TP, GST, TEAC and low GSH level may be relevant to predict congenital defects. |
| Databáze: | OpenAIRE |
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