Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma
| Autor: | Claudia Gundacker, Markus Hengstschläger, Andreas Marius Kaiser, Ingrid Hassl, Martin Forsthuber, Herbert Stangl, Sebastian Granitzer |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty 010504 meteorology & atmospheric sciences Lipoproteins Serum albumin Fractionation 010501 environmental sciences Tandem mass spectrometry 01 natural sciences chemistry.chemical_compound Young Adult Tandem Mass Spectrometry Internal medicine Albumins medicine Humans Bovine serum albumin lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 Fluorocarbons biology Chemistry Cholesterol Albumin Lipids Endocrinology Alkanesulfonic Acids Human plasma Carrier protein biology.protein Environmental Pollutants Female |
| Zdroj: | Environment International, Vol 137, Iss, Pp-(2020) |
| ISSN: | 1873-6750 |
| Popis: | Perfluoroalkyl (PFAS) substances are widespread in the environment and in organisms. The fact that exposure to PFAS is associated with elevated cholesterol levels is a major concern for human health. Previous investigations, in which bovine serum albumin was frequently studied, indicate that PFOS, PFOA and PFNA bind to serum albumin. However, it is critical to know whether these and other PFAS have a preference for the protein or the lipid fraction in native human blood fractions. For this reason, blood samples from four young healthy volunteers (two women, two men, 23–31 years old) were used for protein size separation and fractionation by the Cohn method in combination with serial ultracentrifugation. The plasma fractions were analyzed for 11 PFAS using high-performance tandem mass spectrometry (HPLC-MS/MS). Although the data are based on a small sample, they clearly show that albumin is the most important carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in native human plasma. These five compounds have very little or no affinity for lipoproteins. The confirmation of their transport through albumin is important for the epidemiology of PFAS. The present results must be verified by the examination of a larger number of persons. Keywords: Albumin, Human plasma, perfluoroalkyl substances (PFAS) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect