Test-Retest Reliability of the Binaural Interaction Component of the Auditory Brainstem Response
| Autor: | Alexander T. Ferber, Daniel J. Tollin, Victor Benichoux |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Normalization (statistics)
Sound localization medicine.medical_specialty Guinea Pigs Reproducibility of Results Interaural time difference Context (language use) Monaural Audiology Article 03 medical and health sciences Speech and Hearing 0302 clinical medicine Auditory brainstem response Amplitude Otorhinolaryngology Acoustic Stimulation medicine otorhinolaryngologic diseases Evoked Potentials Auditory Brain Stem Animals 030223 otorhinolaryngology Binaural recording 030217 neurology & neurosurgery Mathematics |
| Popis: | Objectives The binaural interaction component (BIC) is the residual auditory brainstem response (ABR) obtained after subtracting the sum of monaurally evoked from binaurally evoked ABRs. The DN1 peak-the first negative peak of the BIC-has been postulated to have diagnostic value as a biomarker for binaural hearing abilities. Indeed, not only do DN1 amplitudes depend systematically upon binaural cues to location (interaural time and level differences), but they are also predictive of central hearing deficits in humans. A prominent issue in using BIC measures as a diagnostic biomarker is that DN1 amplitudes not only exhibit considerable variability across subjects, but also within subjects across different measurement sessions. Design In this study, the authors investigate the DN1 amplitude measurement reliability by conducting repeated measurements on different days in eight adult guinea pigs. Results Despite consistent ABR thresholds, ABR and DN1 amplitudes varied between and within subjects across recording sessions. However, the study analysis reveals that DN1 amplitudes varied proportionally with parent monaural ABR amplitudes, suggesting that common experimental factors likely account for the variability in both waveforms. Despite this variability, the authors show that the shape of the dependence between DN1 amplitude and interaural time difference is preserved. The authors then provide a BIC normalization strategy using monaural ABR amplitude that reduces the variability of DN1 peak measurements. Finally, the authors evaluate this normalization strategy in the context of detecting changes of the DN1 amplitude-to-interaural time difference relationship. Conclusions The study results indicate that the BIC measurement variability can be reduced by a factor of two by performing a simple and objective normalization operation. The authors discuss the potential for this normalized BIC measure as a biomarker for binaural hearing. |
| Databáze: | OpenAIRE |
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