48-h glucose infusion in humans: effect on hormonal responses, hunger and food intake
| Autor: | Peter J. Havel, Raymond R. Townsend, Karen L. Teff, Maja Petrova |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Leptin
Blood Glucose Male food intake Hunger medicine.medical_treatment Medical and Health Sciences Behavioral Neuroscience chemistry.chemical_compound Eating Ingestion Insulin 2.1 Biological and endogenous factors Infusions Intravenous Saline triglycerides Meal Diabetes digestive oral and skin physiology Biological Sciences Taste Female Intravenous Adult medicine.medical_specialty Infusions insulin Adolescent Adipokine Experimental and Cognitive Psychology Biology Behavioral Science & Comparative Psychology Article Food Preferences Clinical Research Internal medicine Glucose Intolerance medicine Humans insulin sensitivity Obesity Pancreatic hormone Metabolic and endocrine Nutrition Analysis of Variance Triglyceride Prevention Psychology and Cognitive Sciences Endocrinology Glucose chemistry Hyperglycemia Digestive Diseases |
| Zdroj: | Physiology & behavior, vol 90, iss 5 Teff, Karen L; Petrova, Maja; Havel, Peter J; & Townsend, Raymond R. (2007). 48-h glucose infusion in humans: effect on hormonal responses, hunger and food intake.. Physiology & behavior, 90(5), 733-743. doi: 10.1016/j.physbeh.2006.12.013. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4zb639p1 |
| DOI: | 10.1016/j.physbeh.2006.12.013. |
| Popis: | Experimentally-induced hyperglycemia by prolonged glucose infusion allows investigation of the effects of sustained stimulation of the pancreatic beta-cell on insulin secretion and sensitivity. Hormonal responses to a meal following prolonged glucose infusions have not been investigated. To determine if a 48-h glucose infusion alters hormonal responses to a test meal as well as food intake and hunger in normal weight individuals, 16 subjects (8 men, 8 women, age 18-30 years, mean BMI=21.7+/-1.6 kg/m2) were infused for 48 h with either saline (50 ml/h) or 15% glucose (200 mg/m2/min). Subjects ingested a 600 kcal mixed nutrient meal 3 h after infusion termination. Blood samples were taken during the 48 h and for 4 h following food ingestion. The 48-h glucose infusion elicited a metabolic profile of a glucose intolerant obese subjects, with increased plasma glucose, insulin and leptin (all P |
| Databáze: | OpenAIRE |
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