Cyclophilin A: A Predictive Biomarker of Carotid Stenosis in Cerebral Ischemic Stroke

Autor: Chen-Ling Kuo, Chin-San Liu, Shih-Li Su, Ching-Shan Huang, Song-Shei Lin, Chen-Shu Chang, Wan-Min Tseng
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
020205 medical informatics
Carotid Artery
Common
Inflammation
02 engineering and technology
Fibrinogen
Carotid Intima-Media Thickness
Brain Ischemia
03 medical and health sciences
Cellular and Molecular Neuroscience
Cyclophilin A
0302 clinical medicine
Developmental Neuroscience
Predictive Value of Tests
Internal medicine
0202 electrical engineering
electronic engineering
information engineering
Humans
Medicine
cardiovascular diseases
Aged
Analysis of Variance
business.industry
Ultrasound
Middle Aged
medicine.disease
Pathophysiology
Stroke
Stenosis
C-Reactive Protein
ROC Curve
Neurology
030220 oncology & carcinogenesis
Hypertension
Ischemic stroke
cardiovascular system
Cardiology
Biomarker (medicine)
Female
medicine.symptom
business
Biomarkers
medicine.drug
Zdroj: Current Neurovascular Research. 15:111-119
ISSN: 1567-2026
DOI: 10.2174/1567202615666180516120959
Popis: BACKGROUND Cyclophilin A plays a pathogenic role in the development and progression of atherosclerosis, which can be assessed by measuring carotid intima-media thickness. The primary aim of this study was to examine the interaction between plasma Cyclophilin A level and carotid intima-media thickness in patients with acute ischemic stroke. METHOD Plasma concentration of Cyclophilin A was measured on admission in 66 consecutive patients who had been hospitalized for acute cerebral stroke and in 52 case-control subjects without a history of acute stroke. Subjects in both groups also underwent ultrasound B-mode imaging to measure the mean and maximum intima-media thickness of the carotid artery. Inflammatory biomarkers including high-sensitivity C-reactive protein and fibrinogen were also assessed. RESULTS We found that the plasma concentration of Cyclophilin A was significantly higher in patients with acute ischemic stroke (p = 0.042). Increased Cyclophilin A was also correlated with carotid intima-media thickness in the patient group (p < 0.001). Among the risk factors for cerebral stroke examined in this study, only hypertension was significantly associated with plasma Cyclophilin A level. CONCLUSION Increased plasma Cyclophilin A levels might be involved in the pathophysiology of acute ischemic stroke and Cyclophilin A might serve as a biomarker in risk assessment of acute stroke patients.
Databáze: OpenAIRE
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