Synthesis and evaluation of novel dolastatin 10 derivatives for versatile conjugations
| Autor: | Eri Sakurada, Nishio Yukihiro, Akiko Izawa, Shinya Yokosaka, Chizuka Sakai, Yasuhiro Morita |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Clinical Biochemistry
Pharmaceutical Science Antineoplastic Agents 010402 general chemistry 01 natural sciences Biochemistry Mice Structure-Activity Relationship Tubulin Cell Line Tumor Depsipeptides Drug Discovery Cytotoxic T cell Animals Humans Sulfhydryl Compounds Amines Cytotoxicity Molecular Biology IC50 Cell Proliferation Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry 0104 chemical sciences Thiazoles Alcohols Microtubule Inhibitor Molecular Medicine Drug Screening Assays Antitumor |
| Zdroj: | Bioorganicmedicinal chemistry. 26(8) |
| ISSN: | 1464-3391 |
| Popis: | Dolastatin 10 (1) is a highly potent cytotoxic microtubule inhibitor (cytotoxicity IC50 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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