Evaluation of the analgesic and antipyretic activity of methanol extract of Combretum bauchiense Hutch & Dalziel (Combretaceae) leaves
| Autor: | Theodora, Odoh Uchenna Estella, Onugwu Obinna, Obi Patrick, Agubata Chuka William, Chikeoku Ikenna, Uzor Ginikachukwu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Combretaceae
Traditional medicine biology Analgesic General Engineering Combretum Pain biology.organism_classification chemistry.chemical_compound Other systems of medicine chemistry Combretum bauchiense medicine General Earth and Planetary Sciences Antipyretic Methanol Pyrexia RZ201-999 General Environmental Science medicine.drug |
| Zdroj: | Phytomedicine Plus, Vol 2, Iss 1, Pp 100166-(2022) |
| ISSN: | 2667-0313 |
| Popis: | Background: Medicinal plants make up a vital component of therapeutics. The pharmacologic effect of medicinal plants can be said to be related to the nature of their phytochemical constituents or secondary metabolites. Combretum bauchiense is an African folk plant of the family Combretaceae. Over the years Species of the Combretaceae family has been associated with native us as antipyretic and analgesic substances. Aim: This study aims to determine the phytochemical composition and evaluate the analgesic and anti-pyretic activity of the methanol extract of Combretum bauchiense (MECB) leaves. Materials and Methods: The phytochemical analysis and acute toxicity study of MECB was done using standard procedures. The analgesic and antipyretic activity of MECB was investigated using two models each, with Morphine (10 mg/kg) as the standard reference drug for analgesic activity and Paracetamol (150 mg/kg) for antipyretic activity. The analgesic activity of the extract was evaluated using formalin induced pain and tail flick analgesic method and the antipyretic activity was evaluated using baker's yeast and turpentine induced pyrexia. The study was investigated at doses of 100, 200 and 400 mg/kg body weight of the extract. Data was analyzed using One-way Anova followed by Tukey's Post-hoc test and P |
| Databáze: | OpenAIRE |
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