Impaired Blood Rheology and Elevated Remnant-like Lipoprotein Particle Cholesterol in Hypercholesterolaemic Subjects
| Autor: | M Nara, H Sumino, T Machida, H Amagai, K Nakajima, M Murakami |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Time Factors Lipoproteins medicine.medical_treatment Hypercholesterolemia Hematocrit Biochemistry Lipoprotein particle chemistry.chemical_compound Internal medicine medicine Humans Saline Triglycerides Whole blood Triglyceride medicine.diagnostic_test Cholesterol business.industry Biochemistry (medical) Cell Biology General Medicine Blood flow Middle Aged Lipids Red blood cell medicine.anatomical_structure Endocrinology chemistry Female lipids (amino acids peptides and proteins) Rheology business |
| Zdroj: | Journal of International Medical Research. 37:308-317 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/147323000903700204 |
| Popis: | Blood rheology, fasting serum concentrations of remnant-like lipoprotein particle cholesterol (RLP-C) and concentrations of other lipids were compared in 23 hypercholesterolaemic and 69 normocholesterolaemic subjects, and the relationship between red blood cell (RBC) deformability and RLP-C concentrations were studied in a different set of six hypercholesterolaemic and six normocholesterolaemic subjects. Passage time of whole blood and concentrations of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and RLP-C were significantly higher in hypercholesterolaemic than in normocholesterolaemic subjects. Passage time of whole blood correlated positively with TC, TG, LDL-C and RLP-C and negatively with high-density lipoprotein cholesterol. Furthermore, the passage time of 10% haematocrit-adjusted RBCs in phosphate-buffered saline, which reflects RBC deformability, correlated positively with the passage time of whole blood and RLP-C. Thus, hypercholesterolaemic subjects had impaired blood rheology and elevated RLP-C concentrations, which may be associated with the pathophysiology of atherosclerosis in hypercholesterolaemic subjects. Impaired RBC deformability may contribute to impaired blood rheology associated with elevated RLP-C in hypercholesterolaemic subjects. |
| Databáze: | OpenAIRE |
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