Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome?
| Autor: | Didem Demircioğlu, Mehmet Akif Sarıca, Dilek Tuzun, Kamile Gul, Elif İnanç, Murat Sahin, Ayten Oguz |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
endocrine system diseases
Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyroid Gland lcsh:Medicine lcsh:Diseases of the endocrine glands. Clinical endocrinology Body Mass Index Follicle-stimulating hormone 0302 clinical medicine Sex hormone-binding globulin Reference Values insulin resistance Prospective Studies Ultrasonography biology Thyroid Organ Size Polycystic ovary medicine.anatomical_structure 030220 oncology & carcinogenesis luteinizing hormone Female Luteinizing hormone hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome Adult medicine.medical_specialty endocrine system Polycystic ovarian syndrome Adolescent 030209 endocrinology & metabolism Statistics Nonparametric 03 medical and health sciences Young Adult Insulin resistance Thyroid-stimulating hormone Internal medicine medicine Humans lcsh:RC648-665 business.industry Insulin lcsh:R thyroid volume medicine.disease Thyroid Diseases Endocrinology Case-Control Studies biology.protein business Gonadotropins |
| Zdroj: | Archives of Endocrinology and Metabolism, Vol 61, Iss 2, Pp 145-151 Archives of Endocrinology and Metabolism v.61 n.2 2017 Arquivos de Endocrinologia e Metabolismo Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM Archives of Endocrinology and Metabolism, Volume: 61, Issue: 2, Pages: 145-151, Published: 24 NOV 2016 |
| ISSN: | 2359-4292 |
| Popis: | Objective To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS). Subjects and methods 69 new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age 26.69 ± 5.25) were involved to the study. Fasting plasma glucose, lipid profile, insulin, thyroid stimulating hormone (TSH), free thyroxine (fT4), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone levels and urine iodine were measured in all participants. Thyroid and pelvic ultrasound were performed in all participants. Results Insulin, HOMA-IR, LH, E2 and TV were higher in PCOS group (p < 0.05). TV was significantly higher in PCOS patients with IR compared to non-IR PCOS patients (p < 0.001), while TSH, fT4, and urine iodine levels were similar between these groups (p > 0.05). There was a negative correlation between E2 and TSH (p < 0.05) and a positive correlation between TSH and TV (p < 0.05). There was a significant positive correlation between TV and LH, insulin, HOMA-IR (p < 0.05). Conclusion This study showed that TV was increased in patients with insulin resistance but differences in TSH and LH levels may affect TV changes as well. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|