Left Ventricular Systolic Dysfunction in Patients with Obstructive Sleep Apnea Syndrome

Autor: E Orvoen-Frija, Evelyne Bloch, J P Laaban, Ge´rard Huchon, Sophie Pascal-Sebaoun, Jean-Michel Oppert
Rok vydání: 2002
Předmět:
Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Polysomnography
medicine.medical_treatment
Radionuclide ventriculography
Critical Care and Intensive Care Medicine
Severity of Illness Index
Cohort Studies
Positive-Pressure Respiration
Ventricular Dysfunction
Left
Age Distribution
Oxygen Consumption
Radionuclide angiography
Reference Values
Risk Factors
Internal medicine
Positive airway pressure
Prevalence
medicine
Humans
Prospective Studies
Continuous positive airway pressure
Sex Distribution
Systole
Radionuclide Ventriculography
Probability
Sleep Apnea
Obstructive
Ejection fraction
medicine.diagnostic_test
business.industry
Sleep apnea
Middle Aged
medicine.disease
Echocardiography
Doppler
Obstructive sleep apnea
Heart Function Tests
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Magnetic Resonance Angiography
Follow-Up Studies
Zdroj: Chest. 122:1133-1138
ISSN: 0012-3692
Popis: Study objectives Conflicting results have been reported regarding the effects of obstructive sleep apnea syndrome (OSAS) on daytime left ventricular (LV) systolic function. This study aimed to assess the prevalence and causes of LV systolic dysfunction, using radionuclide angiography, in a large group of patients with OSAS. Design and setting A prospective study in the pneumology department of a university medical center. Patients One hundred sixty-nine consecutive patients with OSAS diagnosed by polysomnography, hospitalized for the administration of nasal continuous positive airway pressure. Patients with a known cardiac disease were excluded. Measurements LV ejection fraction (LVEF) was measured in all patients, using radionuclide ventriculography with multiple-gated equilibrium cardiac imaging. Myocardial scintigraphy with a dipyridamole stress test and echocardiography were performed in those patients with LV systolic dysfunction, defined by a LVEF Results LV systolic dysfunction was observed in 7.7% (13 of 169 patients). In these 13 patients, the mean ŷ SD LVEF was 42 ŷ 6%, the lowest value of LVEF was 32%, and no silent cardiac disease was revealed. Age, body mass index, apnea-hypopnea index, parameters of nocturnal oxyhemoglobin desaturation, and prevalence of systemic hypertension did not significantly differ between patients with LVEF 50%. In seven patients with LV dysfunction, LVEF was measured following treatment of OSAS and reached normal values. Conclusion OSAS may be a direct cause of daytime LV systolic dysfunction that can resolve following reversal of nocturnal apneas.
Databáze: OpenAIRE
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