Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: perpetuation by granulocyte colony-stimulating factor
| Autor: | G. F. Lucas, Chrissy Giles, Katy Rezvani, Kate Cwynarski, J. M. Goldman, Christopher Pocock, J. F. Apperley, George S. Vassiliou |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Isoantigens Neutropenia Cell Count Receptors Cell Surface Granulocyte GPI-Linked Proteins Immune system Antigen Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Granulocyte Colony-Stimulating Factor Humans Transplantation Homologous Medicine Autoantibodies Membrane Glycoproteins Leukopenia business.industry Hematopoietic Stem Cell Transplantation Hematology medicine.disease Granulocyte colony-stimulating factor Transplantation medicine.anatomical_structure Immunology Absolute neutrophil count Female medicine.symptom business |
| Zdroj: | British Journal of Haematology. 113:483-485 |
| ISSN: | 0007-1048 |
| Popis: | A case of immune neutropenia following unrelated stem cell transplantation for chronic myeloid leukaemia is described. The neutropenia developed following herpes zoster viral infection and was associated with antibodies to the human neutrophil antigen (HNA)-2a (formerly known as NB1). The neutropenia was prolonged, profound and unresponsive to granulocyte colony-stimulating factor (GCSF). The neutrophil count recovered after GCSF was discontinued. HNA-2a has been reported to be upregulated following GCSF administration. In the present case, it appears that the immune neutropenia may have been perpetuated by GCSF administration. |
| Databáze: | OpenAIRE |
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