Aberrant CD8 Expression in B-Chronic Lymphocytic Leukemia: Report of Five Cases
| Autor: | I. Mazurier, E. Parisi-Duchêne, P. Moskovtchenko |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty CD8 Antigens Biology Immunoglobulin light chain CD19 Immunoglobulin kappa-Chains Immunophenotyping Antigens CD immune system diseases hemic and lymphatic diseases medicine Humans B cell Aged B-Lymphocytes Gene Expression Regulation Leukemic CD23 Hematology General Medicine Middle Aged Flow Cytometry medicine.disease Leukemia Lymphocytic Chronic B-Cell Leukemia medicine.anatomical_structure biology.protein Female CD5 CD8 |
| Zdroj: | Acta Haematologica. 115:74-77 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000089470 |
| Popis: | The expression of T cell-associated antigens on B cell non-Hodgkin lymphoma is rare. We describe 5 cases of B-chronic lymphocytic leukemia (B-CLL) with aberrant expression of CD8 on B cells. These B-CLL presented a typical immunophenotype CD19+, CD23+, FMC7– and CD5+ (except for 1 case) with a monotypic expression of surface immunoglobulin light chain kappa. The CD8 expression was confirmed on B-CLL cells by two-color flow cytometry staining. We could not find coexpression of CD3 or CD4 on B-CLL cells. The clinical implications, the sensitivity to therapy and the prognostic outcome of this aberrant expression remains to be determined. |
| Databáze: | OpenAIRE |
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