Prostate-specific antigen (PSA) as a possible biomarker in non-prostatic cancer: A review
| Autor: | Miguel-Angel Elizondo-Riojas, Diana Cristina Pérez-Ibave, Carlos Horacio Burciaga-Flores |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Male Cancer Research medicine.medical_specialty Epidemiology Colorectal cancer urologic and male genital diseases 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Internal medicine Cancer screening Carcinoma medicine Humans Mass Screening business.industry Cancer Prostatic Neoplasms Prostate-Specific Antigen medicine.disease Prostate-specific antigen 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Biomarker (medicine) Female business |
| Zdroj: | Cancer epidemiology. 54 |
| ISSN: | 1877-783X |
| Popis: | Prostate-specific antigen (PSA) is a serine protease produced by epithelial prostatic cells and its main function is to liquefy seminal coagulum. Currently, PSA is a biomarker for the diagnosis and screening of prostate cancer and it was the first cancer biomarker approved by the FDA. The quantity and serum isoforms of male PSA, allows distinguishing between carcinoma and benign inflammatory disease of the prostate. Initially, it was thought that PSA was produced only by the prostate, and thus, a protein that was expressed exclusively in men. However, several authors report that PSA is a protein that is expressed by multiple non-prostatic tissues not only in men but also in women. Some authors also report that in women, the expression of this protein is highly related to breast and colon cancer and therefore can act as a possible biomarker for early detection, diagnosis and prognosis of these cancers in women. In this review, we will focus on the characteristics of the PSA at a molecular level, its current clinical implications, the expression of this protein in non-prostatic tissues, and its relationship with cancer, especially in women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect