Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model
| Autor: | H Acha-Orbea, A N Shakhov, Jean-Pierre Kraehenbuhl, O Karapetian |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Tumor Virus Infections
Molecular Sequence Data Immunology Mammary gland Polymerase Chain Reaction law.invention Mice Peyer's Patches law medicine Superantigen Animals Immunology and Allergy Mesenteric lymph nodes Lymphocytes Polymerase chain reaction Mice Inbred BALB C Superantigens Base Sequence biology Mouse mammary tumor virus Peyer's patch hemic and immune systems Articles biology.organism_classification Virology medicine.anatomical_structure Lymphatic system Animals Newborn Mammary Tumor Virus Mouse DNA Viral DNA Viral/analysis Lymphocytes/microbiology Mammary Tumor Virus Mouse/genetics Mammary Tumor Virus Mouse/immunology Peyer's Patches/microbiology Retroviridae Infections/etiology Superantigens/immunology Tumor Virus Infections/etiology Retroviridae Infections |
| Zdroj: | Journal of Experimental Medicine, vol. 180, no. 4, pp. 1511-1516 The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.180.4.1511 |
| Popis: | Mouse mammary tumor virus is known to infect newborn mice via mother's milk. A proposed key step for viral spread to the mammary gland is by the infection of lymphocytes. We show here that although in suckling mice retroviral proteins are found in all epithelial cells of the gut, viral DNA is exclusively detectable in the Peyer's patches. As early as 5 d after birth the infection leads to a superantigen response in the Peyer's patches but not in other lymphoid organs draining the intestine. Viral DNA can be detected before the superantigen response and becomes first evident in the Peyer's patches followed by mesenteric lymph nodes and finally all lymphoid organs. |
| Databáze: | OpenAIRE |
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