Amlodipine Reduces Inflammation despite Promoting Albuminuria in the Streptozotocin-Induced Diabetic Rat
| Autor: | Maric-Bilkan C, Elizabeth R. Flynn, Sawyer Rt, Teutsch C, Marbury Dc, Kauser K, Lee J |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure Renal function Kidney lcsh:RC870-923 Internal medicine medicine Amlodipine Inflammation Original Paper Dihydropyridine-type calcium channels business.industry Diabetes Glomerulosclerosis medicine.disease lcsh:Diseases of the genitourinary system. Urology Blood pressure Endocrinology medicine.anatomical_structure Nephrology Albuminuria medicine.symptom business Glomerular hyperfiltration medicine.drug |
| Zdroj: | Nephron Extra, Vol 2, Iss 1, Pp 205-218 (2012) Nephron Extra |
| ISSN: | 1664-5529 |
| Popis: | Amlodipine reduces blood pressure; however, its effect in the diabetic kidney irrespective of its blood pressure-lowering effects is unclear. This study examined the effects of amlodipine (0, 5, 10 and 20 mg/kg; DA0, DA5, DA10 and DA20, respectively) for 12 weeks on renal functional and structural changes in the streptozotocin-induced diabetic rat, a nonhypertensive model of diabetes-associated hyperfiltration. Compared with nondiabetic rats, diabetes (D) was associated with increased urine albumin excretion (UAE, 12.6 ± 3.40 vs. 3.73 ± 1.14 mg/day), glomerular filtration rate (2.17 ± 0.09 vs. 1.64 ± 0.12 ml/min/g kidney weight), glomerulosclerosis (0.21 ± 0.03 vs. 0.05 ± 0.01 AU) and infiltration of inflammatory cells (18.5 ± 2.78 vs. 6.92 ± 0.70 cells/cm2), but did not affect mean arterial pressure (MAP, 110 ± 4.70 vs. 109 ± 5.33 mm Hg). While DA20 abolished glomerular hyperfiltration (1.49 ± 0.05 ml/min/g kidney weight) and inflammatory cell abundance (6.0 ± 0.79 cells/cm2), it exacerbated UAE (43.5 ± 8.49 mg/day) and increased MAP (132 ± 3.76 mm Hg), but had no effect on renal pathology. These data suggest that amlodipine reduces renal inflammation and abolished glomerular hyperfiltration, but increases blood pressure and exacerbates albuminuria in the rat model of normotensive diabetic kidney disease. We conclude that amlodipine may have limited renoprotective effects in the face of hyperfiltration and absence of elevated blood pressure. |
| Databáze: | OpenAIRE |
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