Urinary chemokine C-X-C motif ligand 16 and endostatin as predictors of tubulointerstitial fibrosis in patients with advanced diabetic kidney disease
| Autor: | Sang Youl Rhee, Yang Gyun Kim, Jin Sug Kim, Hoon Young Choi, Sun Hwa Park, Joo Hark Yi, Hyeong Cheon Park, Yu Ho Lee, So-Young Lee, Jeong Taek Woo, Sang-Woong Han, Su Woong Jung, Suk Chon, Young Il Jo, Ju Young Moon, Sang-Ho Lee, Sung Jig Lim, Dong Ho Yang, Kyung Hwan Jeong, Ki Pyo Kim, Dong-Jin Kim |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Urinary system 030232 urology & nephrology Urology Renal function Kidney Function Tests Diabetic nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Biopsy Diabetes Mellitus medicine Humans Diabetic Nephropathies Transplantation Creatinine Kidney medicine.diagnostic_test business.industry Chemokine CXCL16 Middle Aged Prognosis medicine.disease Fibrosis Endostatins Kidney Tubules 030104 developmental biology medicine.anatomical_structure chemistry Nephrology Female Renal biopsy Endostatin business Biomarkers Glomerular Filtration Rate |
| Zdroj: | Nephrology Dialysis Transplantation. 36:295-305 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfz168 |
| Popis: | BackgroundInterstitial fibrosis and tubular atrophy (IFTA) is a well-recognized risk factor for poor renal outcome in patients with diabetic kidney disease (DKD). However, a noninvasive biomarker for IFTA is currently lacking. The purpose of this study was to identify urinary markers of IFTA and to determine their clinical relevance as predictors of renal prognosis.MethodsSeventy patients with biopsy-proven isolated DKD were enrolled in this study. We measured multiple urinary inflammatory cytokines and chemokines by multiplex enzyme-linked immunosorbent assay in these patients and evaluated their association with various pathologic features and renal outcomes.ResultsPatients enrolled in this study exhibited advanced DKD at the time of renal biopsy, characterized by moderate to severe renal dysfunction [mean estimated glomerular filtration rate (eGFR) 36.1 mL/min/1.73 m2] and heavy proteinuria (mean urinary protein:creatinine ratio 7.8 g/g creatinine). Clinicopathologic analysis revealed that higher IFTA scores were associated with worse baseline eGFR (P ConclusionsUrinary CXCL16 and endostatin could reflect the degree of IFTA and serve as biomarkers of renal outcome in patients with advanced DKD. |
| Databáze: | OpenAIRE |
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