PLASMA DOPAMINE-BETA-HYDROXYLASE ACTIVITY IN PHAEOCHROMOCYTOMA
| Autor: | John J. Lilley, Joel Golden, Richard A. Stone |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Tumour heterogeneity biology business.industry Endocrinology Diabetes and Metabolism Healthy subjects Dopamine beta-Hydroxylase Pheochromocytoma Exocytosis Enzyme assay Catecholamines Endocrinology Urinary catecholamine Internal medicine medicine Catecholamine biology.protein Humans Secretion Dopamine beta-hydroxylase activity business medicine.drug |
| Zdroj: | Clinical Endocrinology. 5:181-185 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.1976.tb02830.x |
| Popis: | Plasma dopamine-beta-hydroxylase (DbetaH) activity, a marker of catecholamine secretion that occurs via exocytosis, was determined preoperatively in eight patients with phaeochromocytoma. Despite very elevated urinary catecholamine concentrations, mean plasma DbetaH activity was 32-6 +/- 3 u/l and was not significantly different from apparently healthy subjects. Seven days after surgery, one subject exhibited a 60% postoperative decrease of enzyme activity. These results suggest that diffusion across plasma membranes is the predominant mechanism of catecholamine release from phaeochromocytomas. The postoperative change in one patient suggests tumour heterogeneity and that exocytosis may contribute to the process of catecholamine release in some patients. |
| Databáze: | OpenAIRE |
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