Dose Optimization of Colistin: A Systematic Review
| Autor: | Amal F. Alotaibi, Manal Al-Gethamy, Asim A. Khogeer, Abdul Haseeb, Ahmad Jamal Mahrous, Zikria Saleem, Safa S. Almarzoky Abuhussain, Najla A. Obaid, Aziz Sheikh, Mahmoud E Elrggal, Abdullmoin AlQarni, Hani S. Faidah, Saleh Alghamdi |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Gram-negative infections RM1-950 Biochemistry Microbiology Loading dose law.invention Randomized controlled trial dose optimization law medicine Pharmacology (medical) colistin Dosing General Pharmacology Toxicology and Pharmaceutics business.industry Maintenance dose nephrotoxicity Checklist Infectious Diseases Dose optimization Emergency medicine Colistin Therapeutics. Pharmacology Systematic Review business Cohort study medicine.drug |
| Zdroj: | Haseeb, A, Faidah, H S, Alghamdi, S, Alotaibi, A F, Elrggal, M E, Mahrous, A J, Almarzoky Abuhussain, S S, Obaid, N A, Algethamy, M, Alqarni, A, Khogeer, A A, Saleem, Z & Sheikh, A 2021, ' Dose Optimization of Colistin: A Systematic Review ', Antibiotics, vol. 10, no. 12, pp. 1454 . https://doi.org/10.3390/antibiotics10121454 Antibiotics Antibiotics, Vol 10, Iss 1454, p 1454 (2021) |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics10121454 |
| Popis: | Colistin is considered a last treatment option for multi-drug and extensively resistant Gram-negative infections. We aimed to assess the available data on the dosing strategy of colistin. A systematic review was performed to identify all published studies on the dose optimization of colistin. Grey literature and electronic databases were searched. Data were collected in a specified form and the quality of the included articles was then assessed using the Newcastle-Ottawa scale for cohort studies, the Cochrane bias tool for randomized clinical trials (RCT), and the Joanna Briggs Institute (JBI) critical checklist for case reports. A total of 19 studies were included, of which 16 were cohort studies, one was a RCT, and two were case reports. A total of 18 studies proposed a dosing regimen for adults, while only one study proposed a dosing schedule for pediatric populations. As per the available evidence, a loading dose of 9 million international units (MIU) of colistin followed by a maintenance dose of 4.5 MIU every 12 h was considered the most appropriate dosing strategy to optimize the safety and efficacy of treatment and improve clinical outcomes. This review supports the administration of a loading dose followed by a maintenance dose of colistin in severe and life-threatening multi-drug Gram-negative bacterial infections. |
| Databáze: | OpenAIRE |
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