Fe- and Ln-DOTAm-F12 Are Effective Paramagnetic Fluorine Contrast Agents for MRI in Water and Blood
| Autor: | Małgorzata Marjańska, Kriti Srivastava, Valérie C. Pierre, Evan A. Weitz, Katie L. Peterson |
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| Rok vydání: | 2017 |
| Předmět: |
Iron
Contrast Media chemistry.chemical_element Fluorine-19 NMR 010402 general chemistry Lanthanoid Series Elements 01 natural sciences Inorganic Chemistry Metal Paramagnetism Nuclear magnetic resonance Coordination Complexes medicine Humans Physical and Theoretical Chemistry Aqueous solution Molecular Structure medicine.diagnostic_test 010405 organic chemistry Water Magnetic resonance imaging Fluorine Magnetic Resonance Imaging 0104 chemical sciences Solubility chemistry visual_art visual_art.visual_art_medium Diamagnetism Order of magnitude |
| Zdroj: | Inorganic Chemistry. 56:1546-1557 |
| ISSN: | 1520-510X 0020-1669 |
| DOI: | 10.1021/acs.inorgchem.6b02631 |
| Popis: | A series of fluorinated macrocyclic complexes, M-DOTAm-F12, where M is LaIII, EuIII, GdIII, TbIII, DyIII, HoIII, ErIII, TmIII, YbIII, and FeII, was synthesized, and their potential as fluorine magnetic resonance imaging (MRI) contrast agents was evaluated. The high water solubility of these complexes and the presence of a single fluorine NMR signal, two necessary parameters for in vivo MRI, are substantial advantages over currently used organic polyfluorocarbons and other reported paramagnetic 19F probes. Importantly, the sensitivity of the paramagnetic probes on a per fluorine basis is at least 1 order of magnitude higher than that of diamagnetic organic probes. This increased sensitivity is due to a substantial—up to 100-fold—decrease in the longitudinal relaxation time (T1) of the fluorine nuclei. The shorter T1 allows for a greater number of scans to be obtained in an equivalent time frame. The sensitivity of the fluorine probes is proportional to the T2/T1 ratio. In water, the optimal metal complexes... |
| Databáze: | OpenAIRE |
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