A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres
| Autor: | Ching Fa Yao, Yu Ling Ni, Kang Fang, Chang Hung Hsieh, Jing Ping Wang, Chun Li Su, Seung Hun Kim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Indoles Lung Neoplasms Carcinogenesis Clinical Biochemistry Cell Mice Nude Pharmaceutical Science Antineoplastic Agents Apoptosis Biology medicine.disease_cause Mice 03 medical and health sciences 0302 clinical medicine Cancer stem cell Carcinoma Non-Small-Cell Lung Cell Line Tumor Internal medicine medicine Animals Humans Lung cancer Tumor Stem Cell Assay Cell Proliferation Pharmacology Dose-Response Relationship Drug Cell growth Biochemistry (medical) Cancer Cell Biology medicine.disease Mitochondria 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Neoplastic Stem Cells Quinolines Cancer research Female Neoplasm Transplantation |
| Zdroj: | Apoptosis. 22:1235-1245 |
| ISSN: | 1573-675X 1360-8185 |
| DOI: | 10.1007/s10495-017-1401-3 |
| Popis: | To fight cancer at its roots by targeting cancer stem cells is a promising approach for therapy. Previously, an indolylquinoline derivative, 3-((7-ethyl-1H-indol-3-yl)-methyl)-2-methylquinoline (EMMQ), was reported effectively inhibiting the growth of lung cancer cells through impairment of cellular mitochondria functions. To address more on drug efficiency, the study further exploited if EMMQ can impede the propagation of tumorspheres stemmed from non-small cell lung cancer cells. EMMQ inhibited proliferation of spheroids in culture. In animal models, administration of the drug attenuated the spheroid tumorigenicity. The activated apoptosis alleviated growth of xenograft tumors in immune-deficient mice as established by the enriched tumorspheres. More evidence suggested that the reduced stemness of the spheroid tumors is attributed to apoptotic death. The findings supported that EMMQ is an eligible approach to eradicate the minor but tumorigenic lung cancer tumorspheres. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink