Ovotransferrin Supplementation Improves the Iron Absorption: An In Vitro Gastro-Intestinal Model
| Autor: | Mahitab Farghali, Patrizia Ferraboschi, Laura Saccuman, Francesca Uberti, Paride Grisenti, Rebecca Galla |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
ovotransferrin biology Chemistry QH301-705.5 Ferroportin iron absorption iron transportation Medicine (miscellaneous) Transporter gastro-intestinal barrier Ovotransferrin General Biochemistry Genetics and Molecular Biology In vitro Article Ferritin bovine lactoferrin Biochemistry Transferrin In vivo biology.protein iron metabolism Biology (General) Glycoprotein |
| Zdroj: | Biomedicines Volume 9 Issue 11 Biomedicines, Vol 9, Iss 1543, p 1543 (2021) |
| ISSN: | 2227-9059 |
| Popis: | Transferrins constitute the most important iron regulation system in vertebrates and some invertebrates. Soluble transferrins, such as bovine lactoferrin and hen egg white ovotransferrin, are glycoproteins with a very similar structure with lobes that complex with iron. In this in vitro study, a comparison of bovine lactoferrin and ovotransferrin was undertaken to confirm the comparability of biological effects. An in vitro gastric barrier model using gastric epithelial cells GTL-16 and an in vitro intestinal barrier model using CaCo-2 cells was employed to evaluate iron absorption and barrier integrity. An analysis of the molecular pathways involving DMT-1 (divalent metal transporter 1), ferritin and ferroportin was also carried out. These in vitro data demonstrate the activity of both 15% saturated and 100% saturated ovotransferrin on the iron regulation system. Compared with the commercial bovine lactoferrin, both 15% saturated and 100% saturated ovotransferrin were found to act in a more physiological manner. Based on these data, it is possible to hypothesise that ovotransferrin may be an excellent candidate for iron supplementation in humans in particular, 15% saturated ovotransferrin is the overall best performing product. In vivo studies should be performed to confirm this in vitro data. |
| Databáze: | OpenAIRE |
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