Evaluation of nuclear NF-κB, transglutaminase2, and ERCC1 as predictors of platinum resistance in testicular tumors

Autor: Alan A. Azambuja, Paula Engroff, Bruna T. Silva, Roberta Zorzetti, Fernanda Bueno Morrone
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Oncology
Adult
Male
medicine.medical_specialty
Lung Neoplasms
DNA Repair
Urology
medicine.medical_treatment
030232 urology & nephrology
Bleomycin
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Testicular Neoplasms
GTP-Binding Proteins
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Protein Glutamine gamma Glutamyltransferase 2
Testicular cancer
Etoposide
Retrospective Studies
Cisplatin
Chemotherapy
Transglutaminases
business.industry
transglutaminase 2 [Supplementary Concept]
NF-kappa B
Retrospective cohort study
medicine.disease
Endonucleases
Prognosis
Diseases of the genitourinary system. Urology
DNA-Binding Proteins
chemistry
Drug Resistance
Neoplasm
030220 oncology & carcinogenesis
Immunohistochemistry
Original Article
RC870-923
ERCC1
business
medicine.drug
Zdroj: International braz j urol, Volume: 46, Issue: 3, Pages: 353-362, Published: 30 MAR 2020
International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology
International Brazilian Journal of Urology, Vol 46, Iss 3, Pp 353-362 (2020)
International braz j urol v.46 n.3 2020
International Braz J Urol
Sociedade Brasileira de Urologia (SBU)
instacron:SBU
Popis: Purpose: Testicular germ cells tumor (TGCT) are associated with a high cure rate and are treated with platinum-based chemotherapy. However, a group of testicular cancer patients may have a very unfavorable evolution and insensitivity to the main therapeutic agent chemotherapy (CT) cisplatin. The aim of this study was to evaluate the risk of recurrence and overall survival related to the expression of nuclear factor kappa-B (NF-κB), transglutaminase 2 (TG2) and excision repair cross-complementation group 1 (ERCC1) in patients with TGCT treated with platinum combinations. Patients and Methods: A retrospective study was performed with TGCT patients treated with platinum-based chemotherapy. Immunohistochemical analysis was performed and the expression was correlated with clinical and laboratory data. Results: Fifty patients were included, the mean age was 28.4 years (18 to 45), and 76% were non-seminoma. All patients were treated with standard cisplatin, etoposide and bleomycin or cisplatin, and etoposide. Patient’s analyzed immunodetection for NF-κB, TG2, and ERCC1 were positive in 76%, 54% and 42%, respectively. Multivariate analysis identified that positive expressions to ERCC1 and NF-κB are independent risk factors for higher recurrence TGCT after chemotherapy (RR 2.96 and 3.16, respectively). Patients with positive expression of ERCC1 presented a poor overall survival rate for 10-year follow (p=0.001). Conclusions: The expression of ERCC1 and NF-κB give a worse prognosis for relapse, and only ERCC1 had an influence on the overall survival of TGCT patients treated with platinum-based chemotherapy. These may represent markers that predict poor clinical outcome and response to cisplatin.
Databáze: OpenAIRE
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