Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Autor:	Andrew D. Hamilton, Juliana Ruiz-Caro, Christopher M. Bailey, Karen S. Anderson, Ligong Wang, Aravind Basavapathruni, Joseph T. Kim, William L. Jorgensen
Rok vydání:	2005
Předmět:	Stereochemistry Clinical Biochemistry Human immunodeficiency virus (HIV) Pharmaceutical Science HIV Infections medicine.disease_cause Biochemistry Chemical synthesis Structure-Activity Relationship Drug Resistance Multiple Viral Heterocyclic Compounds Drug Discovery medicine Amines Molecular Biology chemistry.chemical_classification biology Reverse-transcriptase inhibitor Chemistry Organic Chemistry General Medicine biology.organism_classification Nucleotidyltransferase Virology Reverse transcriptase HIV Reverse Transcriptase Thiazoles Enzyme Pyrimidines Enzyme inhibitor Lentivirus biology.protein Molecular Medicine Reverse Transcriptase Inhibitors Nucleoside Hydrophobic and Hydrophilic Interactions medicine.drug
Zdroj:	Bioorganicmedicinal chemistry letters. 16(3)
ISSN:	0960-894X
Popis:	Following computational analyses, potential non-nucleoside inhibitors of HIV-1 reverse transcriptase have been pursued through synthesis and assaying for anti-viral activity. The general class Het–NH–Ph–U has been considered, where Het is an aromatic heterocycle and U is an unsaturated, hydrophobic group. Results for compounds with Het = 2-thiazoyl and 2-pyrimidinyl are the focus of this report.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d4a19ef2f6851387bf9bccfa3ba5fa https://pubmed.ncbi.nlm.nih.gov/16298131 Zobrazit plný text záznamu Full Text from ScienceDirect