Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents
Autor: | Fuchun Lin, Jielan Li, Zhi Wen, Guangyao Wu, Lei Gao, Jing Zhang, Panying Wang, Xi'en Gui, Hao Lei, Ning Tu |
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Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine Cerebellum Adolescent Human immunodeficiency virus (HIV) lcsh:Medicine HIV Infections Biology medicine.disease_cause Gray (unit) Article 03 medical and health sciences 0302 clinical medicine Basal ganglia medicine Humans Gray Matter Child lcsh:Science Anterior cingulate cortex Brain network Multidisciplinary lcsh:R Organ Size Viral Load Magnetic Resonance Imaging Infectious Disease Transmission Vertical CD4 Lymphocyte Count 030104 developmental biology medicine.anatomical_structure Structural covariance Area Under Curve Inferior parietal lobe Female lcsh:Q Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Human immunodeficiency virus (HIV) infection significantly affect neurodevelopmental and behavioral outcomes. We investigated whether alterations of gray matter organization and structural covariance networks with vertical HIV infection adolescents exist, by using the GAT toolbox. MRI data were analysed from 25 HIV vertically infected adolescents and 33 HIV-exposed-uninfected control participants. The gray matter volume (GMV) was calculated, and structural brain networks were reconstructed from gray matter co-variance. Gray matter losses were pronounced in anterior cingulate cortex (ACC), right pallidum, right occipital lobe, inferior parietal lobe, and bilateral cerebellum crus. The global brain network measures were not significantly different between the groups; however, the nodal alterations were most pronounced in frontal, temporal, basal ganglia, cerebellum, and temporal lobes. Brain hubs in the HIV-infected subjects increased in number and tended to shift to sensorimotor and temporal areas. In the HIV-infected subjects, decreased GMVs in ACC and bilateral cerebellum were related to lower Mini-Mental State Examination scores; the CD4 counts were positively related to the GMVs in ACC and sensorimotor areas. These findings suggest that focally reduced gray matter, disrupted nodal profiles of structural wirings, and a shift in hub distribution may represent neuroanatomical biomarkers of HIV infection on the developing brain. |
Databáze: | OpenAIRE |
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