Lethal disseminated tuberculosis in patients under biological treatment – two clinical cases and a short review
| Autor: | Liviu Craciun, Doina Tofolean, Laura Mazilu, Elena Dantes, Ariadna Petronela Fildan, Elena Dumea, Ioan Tiberiu Tofolean |
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| Rok vydání: | 2018 |
| Předmět: |
Medicine (General)
medicine.medical_specialty Tuberculosis Necrosis Case Reports Biochemistry lethal disseminated tuberculosis Arthritis Rheumatoid 03 medical and health sciences R5-920 Fatal Outcome 0302 clinical medicine Psoriasis Internal medicine medicine Humans In patient 030212 general & internal medicine Rheumatoid arthritis TNF-α inhibitors Aged 030203 arthritis & rheumatology Biological Products Ankylosing spondylitis Tumor Necrosis Factor-alpha business.industry Incidence (epidemiology) Biochemistry (medical) Adalimumab psoriasis Cell Biology General Medicine medicine.disease Infliximab Antirheumatic Agents Female Tumor necrosis factor alpha medicine.symptom business |
| Zdroj: | The Journal of International Medical Research Journal of International Medical Research, Vol 46 (2018) |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/0300060518771273 |
| Popis: | Tumour necrosis factor (TNF)-α inhibitors are highly used in Romania for the treatment of autoimmune disorders, such as rheumatoid arthritis (RA), psoriasis, inflammatory bowel diseases, and ankylosing spondylitis. Biological therapy using TNF-α inhibitors is very effective but is associated with an increased risk of opportunistic infections, including active tuberculosis. Here, two cases are presented of patients with RA and psoriasis under biological therapy who developed very aggressive forms of disseminated tuberculosis, with a rapid progression to death. The authors conclude that patients undergoing biological therapy require thorough evaluation prior to initiating treatment, followed by continuous and rigorous monitoring by a multidisciplinary team during biological treatment, particularly in countries with a high incidence of tuberculosis. |
| Databáze: | OpenAIRE |
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