Release mechanisms of acetaminophen from polyethylene oxide/polyethylene glycol matrix tablets utilizing magnetic resonance imaging
| Autor: | Satoshi Kitamura, Masazumi Suzuki, Yukihiro Ozaki, Shigeaki Morita, Ryosaku Sakamoto, Tomokazu Tajiri, Shigeyuki Yamanashi |
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| Rok vydání: | 2009 |
| Předmět: |
Materials science
Diffusion Chemistry Pharmaceutical Drug Compounding Size-exclusion chromatography Pharmaceutical Science macromolecular substances Polyethylene glycol Dosage form Polyethylene Glycols chemistry.chemical_compound Polymer chemistry PEG ratio Spectroscopy Fourier Transform Infrared Technology Pharmaceutical Dissolution Acetaminophen chemistry.chemical_classification Drug Carriers technology industry and agriculture Hydrogels Polymer Analgesics Non-Narcotic Magnetic Resonance Imaging Kinetics chemistry Chemical engineering Solubility Delayed-Action Preparations Chromatography Gel Liberation Tablets |
| Zdroj: | International journal of pharmaceutics. 395(1-2) |
| ISSN: | 1873-3476 |
| Popis: | Release mechanism of acetaminophen (AAP) from extended-release tablets of hydrogel polymer matrices containing polyethylene oxide (PEO) and polyethylene glycol (PEG) were achieved using flow-through cell with magnetic resonance imaging (MRI). The hydrogel forming abilities are observed characteristically and the layer thickness which is corresponding to the diffusion length of AAP has a good correlation with the drug release profiles. In addition, polymeric erosion contribution to AAP releasing from hydrogel matrix tablets was directly quantified using size-exclusion chromatography (SEC). The matrix erosion profile indicates that the PEG erosion kinetic depends primarily on the composition ratio of PEG to PEO. The present study has confirmed that the combination of in situ MRI and SEC should be well suited to investigate the drug release mechanisms of hydrogel matrix such as PEO/PEG. |
| Databáze: | OpenAIRE |
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