Squamous Cell Carcinoma of the Hand: A Retrospective Study in Immunosuppressed and Immunocompetent Individuals
| Autor: | Jamie L. Mull, Patrick S. Phelan, Aaron B. Mull, Aaron J. Russell, Eva A. Hurst, M. Laurin Council |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Dermatology Amputation Surgical Metastasis 030207 dermatology & venereal diseases 03 medical and health sciences Immunocompromised Host 0302 clinical medicine Epidemiology medicine Carcinoma Humans neoplasms Aged Retrospective Studies Aged 80 and over Missouri business.industry Immunosuppression Retrospective cohort study Cell Differentiation General Medicine Middle Aged medicine.disease Hand stomatognathic diseases Amputation 030220 oncology & carcinogenesis Orthopedic surgery Cohort Carcinoma Squamous Cell Surgery Female Neoplasm Recurrence Local business Immunocompetence |
| Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 46(8) |
| ISSN: | 1524-4725 |
| Popis: | Background Cutaneous squamous cell carcinoma (SCC) of the hand presents a treatment challenge because of the anatomical complexity of this location. Immunosuppressed patients are disproportionately affected by cutaneous SCC. Existing data on SCC of the hand are primarily presented in the orthopedic literature, and may thus be affected by referral bias. Objective Characterization of epidemiology and treatment outcomes for hand versus nonhand cutaneous SCC in immunosuppressed versus immunocompetent patients, across all clinical departments. Materials and methods Single-institution retrospective cohort study of cutaneous SCC evaluated over 3 years and hand SCC over an additional 5 years. Results A cohort of 522 hand SCC cases (1,746 total SCC) was ascertained among 1,064 patients, of whom 175 were immunosuppressed. Occurrence on the hand was more common for SCC arising in immunosuppressed versus immunocompetent patients (38% vs 24% of cases respectively). Hand SCC cases demonstrated balanced laterality and comparable spectra of differentiation regardless of immunosuppression. No cases of hand SCC metastasis were observed over greater than 2 years' mean follow-up, and digital amputation was only required in approximately 1% of hand SCCs. Conclusion In our cohort, assessment of hand SCC across all clinical departments suggests more favorable prognosis than reflected in the previous literature. |
| Databáze: | OpenAIRE |
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