Mansoa alliacea extract presents antinociceptive effect in a chronic inflammatory pain model in mice through opioid mechanisms
| Autor: | Henrique Faccin, Luciana Assis Gobo, Fernanda Regina Hamann, Maribel Antonello Rubin, Indiara Brusco, Sara Marchesan Oliveira, Gabriela de Campos Severo, Leandro Machado de Carvalho |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.drug_class Analgesic Arthritis Pharmacology Mansoa alliacea Mice 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Opioid receptor Animals Medicine Inflammation Analgesics Morphine biology Plant Extracts business.industry Cell Biology medicine.disease biology.organism_classification Analgesics Opioid Disease Models Animal 030104 developmental biology Allodynia Opioid Hyperalgesia Chronic Disease Female Chronic Pain medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurochemistry International. 122:157-169 |
| ISSN: | 0197-0186 |
| DOI: | 10.1016/j.neuint.2018.11.017 |
| Popis: | In some chronic disorders, as in arthritis, the inflammatory pain persists beyond the inflammation control becoming pathological. Its treatment shows limited efficacy and adverse effects which compromises patients' quality of life. Mansoa alliacea, known as ‘cipo alho’, is popularly used as analgesic and others species of this genus show anti-inflammatory actions. We investigated the anti-inflammatory and antinociceptive potential of M. alliacea extract in an inflammatory pain model which presents inflammatory characteristics similar to those caused by arthritis, through of the intraplantar injection of complete Freund's adjuvant (CFA) in mice. The extract chromatographic analysis revealed the presence of ρ-coumaric, ferulic and chlorogenic acids, luteolin, and apigenin. The treatment with M. alliacea prevented and reversed the CFA-induced mechanical allodynia with maximum inhibition (Imax) of 100% and 90 ± 10%, respectively. The co-administration of M. alliacea extract plus morphine enhanced the anti-allodynic effect with Imax of 100%. The M. alliacea extract also reverted the CFA-induced thermal hyperalgesia with Imax of 3.6 times greater compared to the vehicle and reduced the thermal threshold under physiological conditions. However, M. alliacea extract did not reduce the CFA-induced edema and myeloperoxidase activity. Additionally, non-selective and δ-selective opioid receptor antagonists, but not κ-opioid, prevented extract anti-allodynic effect with Imax of 98 ± 2% and 93 ± 2%, respectively. Moreover, M. alliacea extract did not induce adverse effects commonly caused by opioids and other analgesic drugs, at least in the tested pharmacological doses after the acute treatment. M. alliacea extract presents antinociceptive activity in an inflammatory pain model, which presents inflammatory characteristics similar to those arthritis-induced, without causing adverse effects in tested pharmacological doses. These effects seem to be mediated mainly via δ-opioid receptors. |
| Databáze: | OpenAIRE |
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