Interactive Effects of Perinatal BPA or DES and Adult Testosterone and Estradiol Exposure on Adult Urethral Obstruction and Bladder, Kidney, and Prostate Pathology in Male Mice
| Autor: | Frederick S. vom Saal, Cynthia Besch-Williford, Julia A. Taylor, Ashley F Berendzen, Maren Bell Jones, William A. Ricke |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine genetic structures Prostate Diseases bisphenol A Prostatic Hyperplasia Diethylstilbestrol Physiology Hydronephrosis urologic and male genital diseases Kidney lcsh:Chemistry Mice Prostate cancer 0302 clinical medicine Pregnancy Prostate benign prostate hyperplasia Testosterone lcsh:QH301-705.5 Spectroscopy Organ Size General Medicine obstructive voiding disorder Computer Science Applications medicine.anatomical_structure Prenatal Exposure Delayed Effects bladder obstruction Biological Assay Female hormones hormone substitutes and hormone antagonists medicine.drug Urethral Obstruction medicine.drug_class Urinary Bladder Prostatitis Article Catalysis Inorganic Chemistry 03 medical and health sciences Phenols prostatitis estradiol medicine Animals Benzhydryl Compounds Physical and Theoretical Chemistry Molecular Biology Genitourinary system business.industry Organic Chemistry medicine.disease 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Estrogen Pregnancy Animal business 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences Volume 21 Issue 11 International Journal of Molecular Sciences, Vol 21, Iss 3902, p 3902 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Obstructive voiding disorder (OVD) occurs during aging in men and is often, but not always, associated with increased prostate size, due to benign prostatic hyperplasia (BPH), prostatitis, or prostate cancer. Estrogens are known to impact the development of both OVD and prostate diseases, either during early urogenital tract development in fetal&ndash neonatal life or later in adulthood. To examine the potential interaction between developmental and adult estrogen exposure on the adult urogenital tract, male CD-1 mice were perinatally exposed to bisphenol A (BPA), diethylstilbestrol (DES) as a positive control, or vehicle negative control, and in adulthood were treated for 4 months with Silastic capsules containing testosterone and estradiol (T+E2) or empty capsules. Animals exposed to BPA or DES during perinatal development were more likely than negative controls to have urine flow/kidney problems and enlarged bladders, as well as enlarged prostates. OVD in adult T+E2-treated perinatal BPA and DES animals was associated with dorsal prostate hyperplasia and prostatitis. The results demonstrate a relationship between elevated exogenous estrogen levels during urogenital system development and elevated estradiol in adulthood and OVD in male mice. These findings support the two-hit hypothesis for the development of OVD and prostate diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |