Fundamental origins and limits for scaling a maternal morphogen gradient
| Autor: | Renjie Jiao, Feng He, Honggang Wu, Chuanxian Wei, David Cheung, Jun Ma |
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| Rok vydání: | 2014 |
| Předmět: |
animal structures
Embryo Nonmammalian DNA Copy Number Variations General Physics and Astronomy Biology Models Biological General Biochemistry Genetics and Molecular Biology Article Morphogenesis Animals Drosophila Proteins Scaling Homeodomain Proteins Multidisciplinary Both ovaries Extramural Ovary Drosophila embryogenesis General Chemistry Anatomy Drosophila melanogaster embryonic structures Trans-Activators Drosophila Female Biological system Morphogen |
| Zdroj: | Nature communications |
| ISSN: | 2041-1723 |
| Popis: | Tissue expansion and patterning are integral to development; however, it is unknown quantitatively how a mother accumulates molecular resources to invest in the future of instructing robust embryonic patterning. Here we develop a model, Tissue Expansion-Modulated Maternal Morphogen Scaling (TEM(3)S), to study scaled anterior-posterior patterning in Drosophila embryos. Using both ovaries and embryos, we measure a core quantity of the model, the scaling power of the Bicoid (Bcd) morphogen gradient's amplitude nA. We also evaluate directly model-derived predictions about Bcd gradient and patterning properties. Our results show that scaling of the Bcd gradient in the embryo originates from, and is constrained fundamentally by, a dynamic relationship between maternal tissue expansion and bcd gene copy number expansion in the ovary. This delicate connection between the two transitioning stages of a life cycle, stemming from a finite value of nA~3, underscores a key feature of developmental systems depicted by TEM(3)S. |
| Databáze: | OpenAIRE |
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