Preanaesthetic Medication with Clonidine
| Autor: | U.A. Carabine, J. Moore, P.M.C. Wright |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Adolescent medicine.drug_class Conscious Sedation Blood Pressure Anxiety Pharmacology Clonidine law.invention Hypnotic Double-Blind Method Randomized controlled trial Preanesthetic Medication Heart Rate law Oral administration Female patient medicine Humans Aged Benzodiazepine Dose-Response Relationship Drug Temazepam business.industry Middle Aged Dose Response Study Anesthesiology and Pain Medicine Anesthesia Female Premedication medicine.symptom business medicine.drug |
| Zdroj: | Survey of Anesthesiology. 36:76 |
| ISSN: | 0039-6206 |
| DOI: | 10.1097/00132586-199204000-00025 |
| Popis: | Eighty normotensive female patients were studied in a randomized, double-blind investigation, in which orally administered clonidine 0.1 mg, 0.2 mg and 0.3 mg were compared with a standard benzodiazepine premedicant. Clonidine 0.2 mg produced a significant reduction in anxiety (P less than 0.05) compared with all the other groups, and a better quality of induction of anaesthesia when compared with temazepam 20 mg and clonidine 0.1 mg. The decreases in arterial pressure and heart rate with clonidine 0.3 mg were significant compared with the other treatment groups. Hypotension persisted into the postoperative period after premedication with clonidine 0.3 mg, and this dose is not recommended as a routine premedicant. |
| Databáze: | OpenAIRE |
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