Do interleukin-1 polymorphisms predict the development of jreiodontitis or the success of dental implants?
| Autor: | Patrick J. Henry, Marina A. Rogers, Gareth Davies, Patricia Price, Albert E. S. Tan, Lisa Figliomeni, Katarina Baluchova |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Heterozygote medicine.medical_specialty Pathology Genotype Sialoglycoproteins medicine.medical_treatment Gingiva Gastroenterology Interferon-gamma Risk Factors Internal medicine medicine Humans Aggressive periodontitis Dental Restoration Failure RNA Messenger Periodontitis Interleukin 6 Alleles Aged Aged 80 and over Dental Implants Polymorphism Genetic biology Interleukin-6 business.industry Homozygote Case-control study Receptors Interleukin-1 Interleukin Middle Aged medicine.disease Interleukin 1 Receptor Antagonist Protein Treatment Outcome Cytokine Aggressive Periodontitis Case-Control Studies biology.protein Periodontics Female Implant business Forecasting Interleukin-1 |
| Zdroj: | Journal of Periodontal Research. 37:37-41 |
| ISSN: | 1600-0765 0022-3484 |
| DOI: | 10.1034/j.1600-0765.2002.00651.x |
| Popis: | Factors which increase the risk of severe adult periodontitis (AP) may also contribute to the success of dental implants. To determine which cytokines may be relevant, levels of interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6) and interferon-gamma (IFN-gamma) mRNA were quantitated in gingival tissue from periodontitis patients and healthy controls. Periodontitis significantly increased levels of IL-1alpha, IL-1beta, IL-6 and IFN-gamma mRNA relative to healthy tissues. IL-1 was selected for further study, as it has inflammatory and bone resorbing properties. We examined IL-1A(-889) and IL-1B(+3953) alleles in Caucasian patients with AP and early-onset periodontitis (EOP), patients with dental implants and healthy individuals. The IL-1B(+3953) polymorphism was associated with AP. This was evident from an increased homozygosity for allele 2 in patients with AP and a decreased heterozygosity in advanced AP patients. IL-1A(-889) and a composite genotype [IL-1A(-889)2 plus IL-1B(+3953)2] showed no association with the incidence of periodontitis, disease onset or disease severity. IL-1A(-889), IL-1B(+3953) and the composite genotype also showed no association with failure of dental implants. |
| Databáze: | OpenAIRE |
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