HLA-DPβ and susceptibility to multiple sclerosis: An analysis of caucasoid and Japanese patient populations
| Autor: | Ann B Begovich, Takeshi Tabira, Rhea C Helmuth, Koichiro Sakai, Henry A. Erlich, Takehiko Sasazuki, Lawrence Steinman, Jorge R. Oksenberg |
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| Rok vydání: | 1990 |
| Předmět: |
HLA-DP Antigens
Multiple Sclerosis Genetic Linkage Molecular Sequence Data Immunology Locus (genetics) Mongoloid Human leukocyte antigen Immunogenetics Biology White People Asian People Gene Frequency Japan medicine Humans Immunology and Allergy Amino Acid Sequence Allele Allele frequency Alleles Genetics Base Sequence Multiple sclerosis General Medicine DNA Probes HLA medicine.disease Restriction fragment length polymorphism |
| Zdroj: | Human Immunology. 28:365-372 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/0198-8859(90)90031-j |
| Popis: | Nonradioactive sequence-specific oligonucleotide (SSO) probes specific for the HLA-DP beta locus have been used in a simple dot-blot assay to DP beta-type samples amplified by the polymerase chain reaction (pcr) from Caucasoid (n = 24) and Japanese (n = 23) patients with multiple sclerosis (ms) as well as ethnically matched controls. In contrast to previous reports, no DP beta allele was found to be increased in either patient population. However, the results do show a dramatic difference in the allele frequencies between the two control populations, further emphasizing the need for ethnically matched controls in studies of HLA and disease. |
| Databáze: | OpenAIRE |
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