Changes in sequences of core region, interferon sensitivity-determining region and interferon and ribavirin resistance-determining region of hepatitis C virus genotype 1 during interferon-alpha and ribavirin therapy, and efficacy of retreatment
| Autor: | Mika Nakaya, Akihiro Tamori, Hideki Fujii, Masaru Enomoto, Tomohiro Ogawa, Ritsuzo Kozuka, Hoang Hai, Atsushi Hagihara, Sawako Kobayashi, Shuji Iwai, Norifumi Kawada, Hiroyasu Morikawa |
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| Rok vydání: | 2012 |
| Předmět: |
Core (anatomy)
Hepatology business.industry Ribavirin Hepatitis C virus virus diseases Alpha interferon medicine.disease_cause Virology digestive system diseases Virological response chemistry.chemical_compound Infectious Diseases chemistry Interferon Hepatitis C virus genotype medicine Amino acid change business medicine.drug |
| Zdroj: | Hepatology Research. 42:1157-1167 |
| ISSN: | 1386-6346 |
| DOI: | 10.1111/j.1872-034x.2012.01046.x |
| Popis: | Aim: Some regions associated with sensitivity to interferon-α and ribavirin have been identified in the hepatitis C virus (HCV) genome, including amino acid 70 in the core region (core a.a. 70), a.a. 2209–2248 (interferon sensitivity-determining region, ISDR) and a.a. 2334–2379 (interferon and ribavirin resistance-determining region, IRRDR). Methods: We examined changes in the sequences of these regions in 25 patients with chronic HCV genotype 1 infection who had not had sustained virological response (SVR) to interferon-α and ribavirin for 24–48 weeks and subsequently received retreatment for 48–72 weeks. Results: At baseline, the core a.a. 70 was mutant (resistant) type in seven patients. At the start of retreatment, the core a.a. 70 had changed from sensitive to resistant type in 2 patients, and SVR was not achieved by retreatment. The ISDR variations were resistant type (0–1 mutations) in 17 patients at baseline. After 2 weeks of treatment, amino acid change was found in two patients; in one, the substitutions returned to baseline status after treatment, and in the other, the substitution persisted. At the start of retreatment, ISDR sequences had changed from resistant to sensitive type in two patients and SVR was achieved and from sensitive to resistant type in three patients and SVR was not achieved. The IRRDR variations were resistant type ( |
| Databáze: | OpenAIRE |
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