Neurophysiological Effects of Corticotropin-Releasing Factor in Living Slices of the Olfactory Area of the Rat Cortex
| Autor: | V. G. Shalyapina, A. A. Mokrushin |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
endocrine system
medicine.medical_specialty Corticotropin-Releasing Hormone Presynaptic Terminals Action Potentials AMPA receptor In Vitro Techniques Inhibitory postsynaptic potential Receptors N-Methyl-D-Aspartate Synaptic Transmission Glutamatergic Postsynaptic potential Internal medicine medicine Animals Receptors AMPA Chemistry General Neuroscience Neural Inhibition Long-term potentiation Olfactory Pathways Rats Cortex (botany) Endocrinology Receptors GABA-B nervous system Excitatory postsynaptic potential NMDA receptor Neuroscience hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuroscience and Behavioral Physiology. 34:1-4 |
| ISSN: | 0097-0549 |
| DOI: | 10.1023/b:neab.0000003240.52437.4b |
| Popis: | Application of corticotropin-releasing factor (CRF) at concentrations of 10(-9) and 10(-8) M to living brain slices induced activation of the pre- and postsynaptic excitatory components of focal potentials recorded in the slices. The amplitudes and durations of the AMPA and NMDA components of EPSP increased during exposure to CRF, while the amplitude of the GABA(B)-mediated IPSP was suppressed. At the higher CRF concentration (10(-8) M), cells in slices showed epileptiform discharges. The effects of CRF were reversible and disappeared on washing. Long-term treatment with CRF (90 min) induced changes in cells in slices similar to those associated with long-term post-tetanic potentiation. These data provide evidence that CRF has marked activatory properties and influences the glutamatergic and GABAergic systems. |
| Databáze: | OpenAIRE |
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