Stage III-IV Sinonasal and Nasal Cavity Carcinoma Treated with Three-Dimensional Conformal Radiotherapy

Autor: Alessandro Boidi Trotti, Massimiliano Garzaro, Michele Zeverino, Anna Maria Gabriele, Cecilia Condello, Mario Airoldi, Simonetta Amerio
Rok vydání: 2008
Předmět:
Adult
Male
Nasal cavity
Cancer Research
medicine.medical_specialty
Maxillary Sinus Neoplasms
Nose Neoplasms
Disease-Free Survival
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Ethmoid Sinus
medicine
Humans
Treatment Failure
Stage (cooking)
Aged
Neoplasm Staging
Retrospective Studies
Aged
80 and over
business.industry
Radiotherapy Dosage
General Medicine
Sinonasal cancer
Middle Aged
Nasal Cavity Carcinoma
Prognosis
Neoadjuvant Therapy
Surgery
Paranasal sinuses
medicine.anatomical_structure
Oncology
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Female
Radiotherapy
Adjuvant
Radiology
Nasal Cavity
Neoplasm Recurrence
Local
Radiotherapy
Conformal
Three dimensional conformal radiotherapy
business
Paranasal Sinus Neoplasms
Follow-Up Studies
Zdroj: Scopus-Elsevier
ISSN: 2038-2529
0300-8916
DOI: 10.1177/030089160809400306
Popis: Aims and Background To report the dosimetric data and clinical outcomes of patients with advanced neoplasm of the paranasal sinuses and nasal cavity, treated by three-dimensional conformal radiotherapy. Methods Between 2000 and 2005, 31 consecutive patients were treated for locally advanced tumors of paranasal sinuses and nasal cavity. The primary tumor was located as follows: maxillary sinus 15 (48.4%); ethmoid sinus 10 (32.3%); nasal cavity 6 (19.3%). The patients were separated in two groups according to the modality of treatment: group Aincluded 21 patients treated with postoperative three-dimensional conformal radiotherapy with or without chemotherapy; group B included 10 patients treated with radical three-dimensional conformal radiotherapy with or without chemotherapy. The median radiation dose to the planning target volume was 60 Gy (range, 56–63) for patients who underwent complete surgical resection and 68 Gy (range, 64–70) for those who did not have tumor resection or patients with residual disease. Results The median follow-up was 42 months. Five-year local tumor control and overall survival actuarial rates were 74% and 72%, respectively, in the postoperative setting, 20% and 25%, respectively, with the primary radiotherapy. Local recurrence was the most common site of failure. No patient developed radio-induced blindness; 4 patients underwent enucleation as part of radical surgery. Dosimetric data are reported. Conclusions The local control rate for these tumors remains low. The prognosis depends on localization, tumor stage and treatment modality. Three-dimensional conformal radiotherapy reduces the risk on optical pathways but does not modify outcome.
Databáze: OpenAIRE
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