Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population

Autor: Huimin Wang, Hao Chen, Boshen Wang, Guangzhi Yang, Dawei Sun, Baoli Zhu, Mengyao Chen
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
Heredity
Epidemiology
Single Nucleotide Polymorphisms
Cardiovascular Medicine
0302 clinical medicine
Medical Conditions
Medicine and Health Sciences
Morphogenesis
Medicine
Public and Occupational Health
Aged
80 and over
Multidisciplinary
Middle Aged
Congenital Heart Defects
Occupational Diseases
Genetic Mapping
Cardiovascular Diseases
Noise
Occupational
Female
Noise-induced hearing loss
Research Article
Adult
Han chinese
China
Adolescent
Science
Occupational disease
Cardiology
Single-nucleotide polymorphism
Variant Genotypes
Polymorphism
Single Nucleotide
03 medical and health sciences
Young Adult
Asian People
Environmental health
Healthy control
otorhinolaryngologic diseases
Genetics
Congenital Disorders
Humans
Birth Defects
Genetic Association Studies
Alleles
Genetic association
Adaptor Proteins
Signal Transducing
Aged
Evolutionary Biology
Population Biology
business.industry
Biology and Life Sciences
medicine.disease
030104 developmental biology
Hearing Loss
Noise-Induced
Haplotypes
Genetic Loci
Medical Risk Factors
Genetic Polymorphism
business
030217 neurology & neurosurgery
Population Genetics
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251090 (2021)
ISSN: 1932-6203
Popis: Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future.
Databáze: OpenAIRE
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