Are perioperative statins beneficial for cardiac surgery?
| Autor: | Gonzalo A Bravo-Soto, Valentina Llovet-Gutiérrez, Gabriel Rada |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
business.industry Treatment outcome MEDLINE General Medicine Perioperative Perioperative Care law.invention Cardiac surgery Systematic review Clinical research Treatment Outcome Randomized controlled trial law Meta-analysis medicine Humans Cardiac Surgical Procedures Hydroxymethylglutaryl-CoA Reductase Inhibitors Intensive care medicine business Randomized Controlled Trials as Topic |
| Zdroj: | Medwave. 17(Suppl1) |
| ISSN: | 0717-6384 |
| Popis: | The use of perioperative statins has been proposed as a measure to reduce morbidity and mortality in cardiac surgery. However, their clinical role is controversial. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified 36 systematic reviews comprising 92 primary studies addressing the question of this article, including 22 randomized trials. We extracted data, combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded perioperative statins probably do not decrease mortality in cardiac surgery and it is unclear if they have any benefit because the certainty of the evidence is very low.Se ha propuesto el uso de estatinas perioperatorias como una medida para disminuir la morbimortalidad en cirugía cardíaca. No obstante, su impacto clínico es controvertido. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en múltiples bases de datos, identificamos 36 revisiones sistemáticas que en conjunto incluyen 92 estudios primarios de los cuales 22 son estudios aleatorizados. Realizamos un metanálisis y tablas de resumen de los resultados utilizando el método GRADE. Concluimos que las estatinas perioperatorias probablemente no disminuyen la mortalidad en cirugía cardíaca y no está claro si tienen algún beneficio porque la certeza de la evidencia es muy baja. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|