Risk of non-melanoma skin cancer in myasthenia patients treated with azathioprine
| Autor: | P. E. H. Jensen, Klaus Hansen, Søren Friis, Jesper Hallas, David Gaist, Emil Greve Pedersen, Anton Pottegård |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Epidemiology Denmark Azathioprine Case-control studies Community Health Planning Internal medicine Myasthenia Gravis Confidence Intervals Odds Ratio Medicine Humans Retrospective Studies business.industry Cumulative dose Incidence (epidemiology) Case-control study Cancer Odds ratio medicine.disease Surgery Logistic Models Oncology Neurology Case-Control Studies Myasthenia Female Neurology (clinical) Skin cancer business Immunosuppressive Agents medicine.drug |
| Zdroj: | Pedersen, E G, Pottegård, A, Hallas, J, Friis, S, Hansen, K, Jensen, P E H & Gaist, D 2014, ' Risk of non-melanoma skin cancer in myasthenia patients treated with azathioprine ', European Journal of Neurology, vol. 21, no. 3, pp. 454-458 . https://doi.org/10.1111/ene.12329 |
| ISSN: | 1468-1331 |
| DOI: | 10.1111/ene.12329 |
| Popis: | Background and purpose: The association between use of azathioprine and risk of non-melanoma skin cancer (NMSC) in patients with myasthenia was evaluated in a nationwide setting. Treatment of autoimmune myasthenia frequently involves long-term exposure to immunosuppressants, including azathioprine. Use of azathioprine increases the risk of NMSC in organ recipients and probably also in patients with other autoimmune disorders. No previous study has specifically investigated the risk of NMSC in myasthenia patients treated with azathioprine. Methods: This is a case-control study based on Danish population-based registries. Cases were myasthenia patients with a first time diagnosis of NMSC during 2004-2009. Age- and sex-matched controls were selected amongst myasthenia patients with no history of cancer using incidence density sampling. Prior use of azathioprine in cases and controls was assessed through prescription records (1995-2009). Conditional logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for skin cancer associated with a high cumulative dose (≥150 g) or long-term use (≥5 years) of azathioprine, adjusted for confounders. Results: Thirty NMSC cases and 360 matched controls were identified. Ever use of azathioprine was associated with a considerably increased risk of NMSC (OR 3.3, 95% CI 1.5-7.3) that was even more apparent in patients with high cumulative dose (OR 4.6, 95% CI 1.7-12.5) or long-term (OR 4.8; 95% CI 1.7-13.6) use of azathioprine. Conclusion: Azathioprine use in patients with myasthenia is associated with an increased risk of NMSC. |
| Databáze: | OpenAIRE |
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