Pharmacokinetic evaluation of formulated levodopa methyl ester nasal delivery systems
| Autor: | Kyung Eun Lee, In Koo Chun, Hye Sun Gwak, Jeong Yeon Rhie, In Kyung Yoon, Yeon Hong Lee, Kyung Hee Kim |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pharmacology Levodopa Chemistry Chemistry Pharmaceutical Levodopa methyl ester Area under the curve Biological Availability Rats nervous system diseases Rats Sprague-Dawley Drug Delivery Systems Pharmacokinetics In vivo Carbidopa NASAL PREPARATIONS medicine Animals Pharmacology (medical) Nasal administration Administration Intranasal medicine.drug |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 39:237-242 |
| ISSN: | 2107-0180 0378-7966 |
| DOI: | 10.1007/s13318-013-0171-8 |
| Popis: | The objective of this study was to investigate the pharmacokinetic characteristics of levodopa (L-dopa) from nasal powder formulations using highly water-soluble levodopa methyl ester hydrochloride (LDME). In vivo pharmacokinetic studies were carried out with formulated LDME nasal powders. After oral and intravenous administration of L-dopa and carbidopa and intranasal administration LDME to the rat, L-dopa concentrations were determined in plasma and the brain using high-performance liquid chromatography. The absolute bioavailabilities of nasal preparations with and without Carbopol were 82.4 and 66.7 %, respectively, which were much higher than that of oral delivery (16.2 %). The drug-targeting efficiencies [area under the curve (AUC) in brain/AUC in plasma] of L-dopa in the nasal formulations (0.98-1.08) were much higher than that of oral preparation (0.69). These results suggest that LDME nasal powder formulations would be useful delivery systems of L-dopa to the brain. |
| Databáze: | OpenAIRE |
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