Postnatal development of alkaline phosphatase activity correlates with the maturation of neurotransmission in the cerebral cortex

Autor: László Négyessy, Caroline Fonta, Pascal Barone, Luc Renaud
Přispěvatelé: Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Anatomy, Histology and Embryology, Semmelweis University [Budapest]
Rok vydání: 2005
Předmět:
Aging
Neuropil
MESH: Callithrix
Nerve Fibers
Myelinated
Synaptic Transmission
MESH: Animals
Newborn
MESH: Synapses
Myelin
0302 clinical medicine
MESH: Alkaline Phosphatase
Thalamus
MESH: Presynaptic Terminals
MESH: Glial Fibrillary Acidic Protein
MESH: Aging
MESH: Animals
Visual Cortex
MESH: Thalamus
0303 health sciences
Node of Ranvier
General Neuroscience
Callithrix
Cell Differentiation
Immunohistochemistry
MESH: Nerve Fibers
Myelinated
medicine.anatomical_structure
Cerebral cortex
MESH: Microscopy
Electron
Transmission
Alkaline phosphatase
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
MESH: Cell Differentiation
Synaptic cleft
Presynaptic Terminals
Biology
Neurotransmission
Electron Transport Complex IV
03 medical and health sciences
MESH: Neuropil
MESH: Electron Transport Complex IV
Microscopy
Electron
Transmission
Neuroplasticity
Glial Fibrillary Acidic Protein
Ranvier's Nodes
medicine
MESH: Synaptic Transmission
Animals
Visual Pathways
030304 developmental biology
MESH: Visual Pathways
MESH: Visual Cortex
MESH: Biological Markers
MESH: Immunohistochemistry
Alkaline Phosphatase
Visual cortex
nervous system
Animals
Newborn
Synapses
MESH: Ranvier's Nodes
Neuroscience
030217 neurology & neurosurgery
Biomarkers
Zdroj: Journal of Comparative Neurology
Journal of Comparative Neurology, Wiley, 2005, 486 (2), pp.179-96. ⟨10.1002/cne.20524⟩
ISSN: 0021-9967
1096-9861
DOI: 10.1002/cne.20524⟩
Popis: International audience; We have shown previously that the tissue nonspecific alkaline phosphatase (TNAP) is selectively expressed in the synaptic cleft of sensory cortical areas in adult mammals and, by using sensory deprivation, that TNAP activity depends on thalamocortical activity. We further analyzed this structural functional relationship by comparing the developmental pattern of TNAP activity to the maturation of the thalamocortical afferents in the primate brain (Callithrix jacchus). Cortical expression of alkaline phosphatase (AP) activity reflects the sequential maturation of the modality-specific sensory areas. Within the visual cortex, the regional and laminar distribution of AP correlates with the differential maturation of the magno- and parvocellular streams. AP activity, which is transiently expressed in the white matter, exhibits a complementary distributional pattern with myelin staining. Ultrastructural analysis revealed that AP activity is localized exclusively to the myelin-free axonal segments, including the node of Ranvier. It was also found that AP activity is gradually expressed in parallel with the maturation of synaptic contacts in the neuropile. These data suggest the involvement of AP, in addition to neurotransmitter synthesis previously suggested in the adult, in synaptic stabilization and in myelin pattern formation and put forward a role of AP in cortical plasticity and brain disorders.
Databáze: OpenAIRE
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