Occurrence of Cranial Neoplasms in Pediatric Patients with Noonan Syndrome Receiving Growth Hormone: Is Screening with Brain MRI prior to Initiation of Growth Hormone Indicated?
| Autor: | Jadranka Popovic, Pedro Pagan, Oscar Escobar, Kanthi Bangalore Krishna |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Male medicine.medical_specialty Pathology Endocrinology Diabetes and Metabolism Tumor burden 030209 endocrinology & metabolism Growth hormone Short stature Article 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Brain mri Humans Exome Primary Brain Tumors Insulin-Like Growth Factor I Growth Disorders business.industry Sequence Analysis DNA medicine.disease Growth hormone treatment Pediatrics Perinatology and Child Health Noonan syndrome Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Horm Res Paediatr |
| Popis: | Noonan syndrome (NS) is associated with short stature. Growth hormone treatment has been FDA approved for use in these patients. Children with NS are at a higher risk of developing benign and malignant proliferative disorders, primary brain tumors being one of them. Since growth hormone therapy can worsen the tumor burden, screening with a brain MRI prior to growth hormone initiation in NS patients is strongly recommended. Here we present two NS patients who developed different primary brain tumors while being on growth hormone therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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