Efficacy of 10% imidacloprid + 2.5% moxidectin topical solution (Advantage Multi® for Dogs) for the prevention of heartworm disease and infection all month long
| Autor: | Cameon M. Ohmes, Joseph A. Hostetler, Terry Settje, Dwight D. Bowman, Samuel Charles, Daniel Keil |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Advantage Multi® for Dogs Dirofilaria immitis 030231 tropical medicine Persistent efficacy Physical examination Advantage Multi Gastroenterology Heartworm disease lcsh:Infectious and parasitic diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Imidacloprid Forward protection Internal medicine parasitic diseases medicine lcsh:RC109-216 Adverse effect biology medicine.diagnostic_test business.industry 030108 mycology & parasitology biology.organism_classification Moxidectin Surgery Moxidectin Topical Solution Infectious Diseases chemistry All-month protection Parasitology business |
| Zdroj: | Parasites & Vectors, Vol 10, Iss S2, Pp 59-64 (2017) |
| ISSN: | 1756-3305 |
| DOI: | 10.1186/s13071-017-2432-x |
| Popis: | Background Prior work has shown that the levels of moxidectin in dogs treated with Advantage Multi® for Dogs (Bayer Animal Health) remain at a high plasma concentration for the full month after application. The objective of this study was to demonstrate the efficacy of 10% imidacloprid + 2.5% moxidectin topical solution (Advantage Multi® for Dogs, also known as Advocate® for Dogs) for the prevention of heartworm infection and disease 30 days after just one application. Methods Two groups of eight dogs each were included. Dogs in Group 1 received the product (Advantage Multi® for Dogs) while those in Group 2 remained as nontreated controls. All dogs entering the study completed a physical examination including examination for Dirofilaria immitis antigen and circulating microfilariae. Dogs in Group 1 were treated on Study Day (SD) –30 as per the label recommendation. Thirty days later (SD 0) dogs in Groups 1 and 2 were subcutaneously infected in the inguinal region with approximately 50 infective third-stage D. immitis larvae (“Missouri” isolate). Blood was collected on SDs 120 and 147 for examination for D. immitis antigen and circulating microfilariae. On SD 148, all animals were euthanized and necropsied for recovery of adult heartworms. All procedures were performed in accordance with the VICH GL9 guidelines. Results Examination and worm counts made at necropsy showed no heartworms in the treated dogs (Group 1) compared with six of eight nontreated dogs (Group 2) with heartworms (range of 2–33). The treated dogs (Group 1) had significantly fewer heartworms (p |
| Databáze: | OpenAIRE |
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