Evaluation of the antipsychotic potential of aqueous fraction of Securinega virosa root bark extract in mice
| Autor: | M. Mohammed, Aliyu M. Musa, Mohammed Garba Magaji, I.M. Hussaini, Ibrahim Abdu-Aguye, R.A. Magaji |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Apomorphine Drug Evaluation Preclinical Fraction (chemistry) Catalepsy Pharmacology Plant Roots Biochemistry law.invention Mice Cellular and Molecular Neuroscience law medicine Haloperidol Animals Medicine African Traditional Swimming Dose-Response Relationship Drug biology Plant Extracts Chemistry Methanol Euphorbiaceae Water medicine.disease biology.organism_classification Grooming Disease Models Animal Dose–response relationship visual_art Plant Bark Solvents visual_art.visual_art_medium Female Bark Neurology (clinical) Stereotyped Behavior Phytotherapy human activities Antipsychotic Agents medicine.drug |
| Zdroj: | Metabolic Brain Disease. 29:161-165 |
| ISSN: | 1573-7365 0885-7490 |
| Popis: | Securinega virosa(Roxb ex. Willd) Baill. is a plant which is commonly used in African traditional medicine in managementof mental illness. Previous study showedthat the crude methanolic root bark extract of the plant possesses antipsychotic activity. In this study, the antipsychotic potential of the residual aqueous fraction of the plant was evaluated using two experimental models, apomorphine induced stereo- typic climbing behaviour and swim induced grooming, all in mice. The effect of the fraction on haloperidol-induced cata- lepsy was also evaluated. The fraction significantly reduced the mean climbing score at the highest dose tested (500 mg/kg). In the swim-induced grooming test, the fraction significantly and dose-dependently (125-500 mg/kg) de- creased the mean number and mean duration of swim- induced grooming activity in mice. Similarly, the standard haloperidol (1 mg/kg) significantly (p |
| Databáze: | OpenAIRE |
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