Non-invasive vagus nerve stimulation for treatment of cluster headache: early UK clinical experience

Autor: Candace McClure, Elizabeth Consiglio, Eric Liebler, Nicola Giffin, Juana Marin, Brendan Davies
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Neurology
Adolescent
Vagus Nerve Stimulation
medicine.medical_treatment
lcsh:Medicine
Cluster Headache
03 medical and health sciences
Young Adult
0302 clinical medicine
Refractory
Statistical significance
Internal medicine
medicine
Humans
030212 general & internal medicine
Adverse effect
Aged
Retrospective Studies
Analgesics
business.industry
Neuromodulation
Cluster headache
Non invasive
lcsh:R
Non-invasive vagus nerve stimulation
General Medicine
Middle Aged
medicine.disease
Combined Modality Therapy
United Kingdom
Real-world data
Clinical trial
Anesthesiology and Pain Medicine
Treatment Outcome
Female
Neurology (clinical)
business
Preventive therapy
Acute treatment
030217 neurology & neurosurgery
Vagus nerve stimulation
Research Article
Chronic cluster headache
Zdroj: The Journal of Headache and Pain
The Journal of Headache and Pain, Vol 19, Iss 1, Pp 1-6 (2018)
ISSN: 1129-2377
Popis: Background Evidence supports the use of non-invasive vagus nerve stimulation (nVNS; gammaCore®) as a promising therapeutic option for patients with cluster headache (CH). We conducted this audit of real-world data from patients with CH, the majority of whom were treatment refractory, to explore early UK clinical experience with nVNS used acutely, preventively, or both. Methods We retrospectively analysed data from 30 patients with CH (29 chronic, 1 episodic) who submitted individual funding requests for nVNS to the National Health Service. All patients had responded to adjunctive nVNS therapy during an evaluation period (typical duration, 3–6 months). Data collected from patient interviews, treatment diaries, and physician notes were summarised with descriptive statistics. Paired t tests were used to examine statistical significance. Results The mean (SD) CH attack frequency decreased from 26.6 (17.1) attacks/wk. before initiation of nVNS therapy to 9.5 (11.0) attacks/wk. (P
Databáze: OpenAIRE
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