Digital gene atlas of neonate common marmoset brain
| Autor: | Karl J. Windak, Aya C. Yoshida, Ayumi Abe, Masae Sato, Tsuna Serizawa, Kanako Saga, Takuro Yoshimoto, Tomomi Shimogori, Mami Tanaka, Satomi S. Kikuchi, Miyano Sakurai, Mami U, Hirozumi Nishibe, Sachie Suzuki, Mitsuhiro Toki, Kimie Niimi, Tomoko Yoda, Yoshiaki Kita, Eiki Takahashi, Shoji Tatsumoto, Yan Wang, Hideyuki Okano, Tsutomu Hashikawa, Yasuhiro Go, Chihiro Yoshida, Noriyuki Kishi, Misako Okuno, Haruhiko Yamagishi, Keiko Yamashita |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system animal structures Gene Expression Brain research Macaque Animals Genetically Modified 03 medical and health sciences Cognition 0302 clinical medicine biology.animal Animals Primate Gene biology General Neuroscience Brain Marmoset Callithrix General Medicine biology.organism_classification body regions Disease Models Animal 030104 developmental biology Macaca Neuroscience research Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Research. 128:1-13 |
| ISSN: | 0168-0102 |
| DOI: | 10.1016/j.neures.2017.10.009 |
| Popis: | Interest in the common marmoset (Callithrix jacchus) as a primate model animal has grown recently, in part due to the successful demonstration of transgenic marmosets. However, there is some debate as to the suitability of marmosets, compared to more widely used animal models, such as the macaque monkey and mouse. Especially, the usage of marmoset for animal models of human cognition and mental disorders, is still yet to be fully explored. To examine the prospects of the marmoset model for neuroscience research, the Marmoset Gene Atlas (https://gene-atlas.bminds.brain.riken.jp/) provides a whole brain gene expression atlas in the common marmoset. We employ in situ hybridization (ISH) to systematically analyze gene expression in neonate marmoset brains, which allows us to compare expression with other model animals such as mouse. We anticipate that these data will provide sufficient information to develop tools that enable us to reveal marmoset brain structure, function, cellular and molecular organization for primate brain research. |
| Databáze: | OpenAIRE |
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