Corneal epithelium tissue engineering: recent advances in regeneration and replacement of corneal surface
| Autor: | Akram Alizadeh, Zahra Gholami Mahmoudian, Jafar Majidi, Hamed Nosrati, Mahdi Zafari, Shiva Asadpour, Zahra Abpeikar, Lida Moradi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Embryology
medicine.medical_specialty genetic structures Keratoprosthesis medicine.medical_treatment Biomedical Engineering Corneal Diseases Cornea 03 medical and health sciences 0302 clinical medicine Tissue engineering Biological property Ophthalmology medicine Humans Regeneration Corneal surface Corneal transplantation 030304 developmental biology Corneal epithelium 0303 health sciences Tissue Engineering business.industry Regeneration (biology) Epithelium Corneal Prostheses and Implants eye diseases medicine.anatomical_structure 030221 ophthalmology & optometry sense organs business |
| Zdroj: | Regenerative Medicine. 15:2029-2044 |
| ISSN: | 1746-076X 1746-0751 |
| Popis: | Currently, many corneal diseases are treated by corneal transplantation, artificial corneal implantation or, in severe cases, keratoprosthesis. Owing to the shortage of cornea donors and the risks involved with artificial corneal implants, such as infection transmission, researchers continually seek new approaches for corneal regeneration. Corneal tissue engineering is a promising approach that has attracted much attention from researchers and is focused on regenerative strategies using various biomaterials in combination with different cell types. These constructs should have the ability to mimic the native tissue microenvironment and present suitable optical, mechanical and biological properties. In this article, we review studies that have focused on the current clinical techniques for corneal replacement. We also describe tissue-engineering and cell-based approaches for corneal regeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|