A new lindenane-type sesquiterpenoid lactone from Chloranthus japonicus

Autor:	Cheng-Shi Jiang, Gui-Hua Tang, Yan-Qiong Guo, Sheng Yin, Hua Zhang
Rok vydání:	2018
Předmět:	Magnetic Resonance Spectroscopy Chloranthus japonicus Stereochemistry Pharmaceutical Science 01 natural sciences Analytical Chemistry Lactones Magnoliopsida chemistry.chemical_compound Phosphodiesterase-4 Drug Discovery Pharmacology chemistry.chemical_classification biology 010405 organic chemistry Chemistry Rosmarinic acid Organic Chemistry General Medicine biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Molecular Medicine Phosphodiesterase 4 Inhibitors Sesquiterpenes Two-dimensional nuclear magnetic resonance spectroscopy Chloranthaceae Derivative (chemistry) Lactone
DOI:	10.6084/m9.figshare.5793717
Popis:	Chromatographic fractionation of the EtOH extracts of the Traditional Chinese Medicine (TCM) Chloranthus japonicus, has led to the isolation of a new lindenane-type sesquiterpenoid lactone derivative (1). Rosmarylchloranthalactone E (1), which consists of lindenane sesquiterpenoid lactone and rosmarinic acid moieties linked via an ester bridge, was structurally elucidated by 1D and 2D NMR and HRMS data. Compound 1 was a potent phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 0.96 ± 0.04 μM.
Databáze:	OpenAIRE
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