Successful Treatment of Pulmonary Invasive Aspergillosis with Voriconazole in Patients who Failed Conventional Therapy

Autor: Lenka Kolarova, Daniel Pablo Lew, A. Ondrusova, Jorge Garbino, Peter Rohner
Rok vydání: 2003
Předmět:
Adult
Male
Microbiology (medical)
medicine.medical_specialty
Antifungal Agents
medicine.medical_treatment
Microbial Sensitivity Tests
Aspergillosis
Severity of Illness Index
Aspergillosis/diagnosis/ drug therapy
Drug Administration Schedule
Sampling Studies
Pulmonary invasive aspergillosis
Drug Resistance
Fungal
Humans
Medicine
In patient
Triazoles/ administration & dosage
Intensive care medicine
Aged
ddc:616
Voriconazole
Chemotherapy
Dose-Response Relationship
Drug
Lung Diseases
Fungal
business.industry
Incidence (epidemiology)
Respiratory disease
Lung Diseases
Fungal/ drug therapy/microbiology
General Medicine
Middle Aged
Triazoles
medicine.disease
Pyrimidines/ administration & dosage
Pyrimidines
Treatment Outcome
Infectious Diseases
Lung disease
Antifungal Agents/pharmacology/ therapeutic use
Fungemia/diagnosis/ drug therapy
Tomography
X-Ray Computed
business
Fungemia
Follow-Up Studies
medicine.drug
Zdroj: Infection, Vol. 31, No 4 (2003) pp. 241-243
ISSN: 1439-0973
0300-8126
DOI: 10.1007/s15010-003-3176-4
Popis: BACKGROUND: The incidence of fungal infections, including those due to Aspergillosis species has continued to increase in recent years. Invasive aspergillosis remains an important cause of morbidity and mortality, despite therapeutics interventions. PATIENTS AND METHODS: We reported five cases of invasive pulmonary aspergillosis treated with voriconazole failing to respond to conventional treatments. RESULTS: The clinical and radiological resolution of pulmonary aspergillosis reported in these cases following therapy with voriconazole is remarkable, considering the infections had proved refractory to standard antifungal therapies. Long-term therapy (in two cases > or = 1 year, in one case 6 months) was very well tolerated by patients who were unable to tolerate other antifungal agents. CONCLUSION: Therapy with voriconazole offers a new therapeutic option for otherwise difficult-to-treat infections and the potential to significantly improve the management of Aspergillosis infections.
Databáze: OpenAIRE
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