STUDY OF THE INFLUENCE OF L-NORVALINE, ROSUVASTATIN AND THEIR COMBINATION ON THE LEVEL OF MICROCIRCULATION IN BONE TISSUE IN EXPERIMENTAL OSTEOPOROSIS AND FRACTURES ON ITS BACKGROUND
| Autor: | A.A. Dolzhikov, Gudyrev Os, A.A. Stepchenko, D. S. R. Rajkumar, A V Faitel'son, S.V. Povetkin |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Osteoporosis microcirculation RM1-950 osteoporotic fracture Bone tissue endothelial dysfunction Microcirculation chemistry.chemical_compound Bivalos Internal medicine medicine microcirculat Osteoporotic fracture Rosuvastatin Endothelial dysfunction business.industry General Medicine medicine.disease osteoporosis medicine.anatomical_structure Endocrinology chemistry Therapeutics. Pharmacology Norvaline business L-norvaline rosuvastatin medicine.drug |
| Zdroj: | Research Results in Pharmacology 2(1): 20-24 Research Results in Pharmacology, Vol 2, Iss 1, Pp 20-24 (2016) |
| ISSN: | 2658-381X |
| Popis: | The experiment was carried out in female white Wistar rats to investigate the effect of L-norvaline, rosuvastatin and their combination on parameters of blood supply to the bone tissue on models of experimental osteoporosis and osteoporotic fractures. It was found that the studied drugs prevent reduction of microcirculation in osteoporotic bone tissue as well as in callus tissue of experimental osteoporotic fractures and it positively influences the course of reparative regeneration of bone tissue. |
| Databáze: | OpenAIRE |
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